25% RRR reported as the key secondary endpoint: composite of cardiovascular death, MI or
stroke. HR: 0.75; 95% CI: 0.62-0.91; p=0.003. ARR: 3.2%; 95% CI: 1.2-5.2.
ACS = Acute coronary syndrome; ARR = Absolute risk reduction; CV = Cardiovascular; EAS = European Atherosclerosis Society; ESC = European Society of Cardiology; EVOPACS = EVOlocumab for Early
Reduction of LDL-cholesterol Levels in Patients With Acute Coronary Syndromes; FOURIER = Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects
with Elevated Risk; LDL-C = Low-density lipoprotein cholesterol; MI = Myocardial infarction; PAD = Peripheral artery disease; PCSK9 = Protein convertase subtilisin/kexin type 9;
RRR = Relative risk reduction.
Repatha® (evolocumab) Summary of Product Characteristics. Last revised: 31 March 2021.
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